Cytotoxic Activity of 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone on Colon Cancer Cell WiDr

Nur Ismiyati, Yuli Puspito Rini, Andi Eko Wibowo, Ratna Asmah Susidarti

Abstract


Colon cancer is one of the most common death-caused cancer. The high mortality rate indicates that chemotherapy has not overcome cancer disease. Strategies and development of colon cancer treatment should be pursued. Compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone is the 2ʹ,5ʹ-dihydroxychalcone derivative, of which the B ring was substituted with 2-pyridine ring. Chalcone and its derivatives have been reported to have several biological activities, such as cytotoxic, anti-inflammatory, antiHIV, and as a tyrosine kinase inhibitor. The objectives of this research was to determine the cytotoxic activity on WiDr colon cancer cells of 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone. Cytotoxic activity was measured using MTT assay. Compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone inhibited WiDr cell growth with the IC50 of  16 µM. Morphology of WiDr cell showed that compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone inhibited cell growth in dose dependent.

Keywords:  compound 1-(2,5-dihydroxyphenyl)-3-pyridine-2-yl-propenone, WiDr colon cancer cell line, cytotoxic activity


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References


Arkenau, H.T., Rettig, K. and Porschen, R., 2005, Adjuvant Chemotherapy in Curative Resected Colon Carcinoma: 5-Fluorouracil/Leucovorin versus High-dose 5-Fluorouracil 24-h Infusion/Leucovorin versus High-dose 5-Fluorouracil 24-h Infusion , Int. J. Colorectal Dis., 20, 258-261.

Ikawati, Muthi, 2008, Modulasi Daur Sel dan Pemacuan Apoptosis pada Sel Kanker Kolon Widr oleh Perlakuan Tunggal Pentagamavunon-0 dan Kombinasinya dengan 5-Fluorouracil, Tesis, Universitas Gadjah Mada.

Meyerhardt, J.A., and Mayer, R.J., 2005, Systemic Therapy for Colorectal Cancer, N. Engl. J. Med., 352(5), 476-487.

Patil, B. C., Mahajan, S.K., and Katti, A.S. 2009, Chalcone: A Versatile Molecule, Journal of Pharmaceutical Sciences and Research, 1, 11-22.

Pusponegoro, A.D., 2004, Epidemiologi keganasan saluran cerna. Proceeding Temu Ilmiah Multimodalitas Terapi Pada Keganasan Saluran Cerna, Jakarta : 36-42.

Saxena H. O., Faridi U., Kumar J. K., Luqman S., Darokar M. P., Shanker K., Chanotiya C. S., Gupta M. M., and Negi A. S., 2007, Synthesis Of Chalcone Derivatives On Steroidal Framework and Their Anticancer Activities, Steroids, 72, 892-900.

Turini, M. E. and DuBois, R. N., 2002, Cyclooxygenase¬2: A Therapeutic Target, Annu. Rev. Med. , 53, 35–57.




DOI: http://dx.doi.org/10.14499/indonesianjcanchemoprev6iss1pp12-15

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