The Effect of Co-Administration of Telang Leaves Ethanolic Extract Towards Fluoxetin’s Sedative Effect on Male Balb/C Mice Based on Sleeping Duration Parameter

Anif Nur Artanti, Maria Ulfah


One of Telang plant’s advantages is its activity as sedative agent. Previous studies indicate that Telang plant has anticonvulsant activity on mice at certain dose. This study was conducted to find out the sedative effect of Telang plant, particularly its leaf, when being co-administered with fluoxetin. Phytochemical analysis was carried out qualitatively on Telang ethanolic extract leaves (TEE) to find out the content of chemical compound first.

This study was an experimental research with post-test only control group design, employing male balb/c mice. The effect of Telang ethanolic extract co-administration with fluoxetin was observed. The parameter being used in the study was the duration of sleep. Analysis was done by comparing mice sleeping duration prior to administration of fluoxetin alone and in combination with Telang ethanolic extract. The data was then analyzed using SPSS 17.0 for Windows.

The results showed that TEE contained tannin, saponin, and flavonoid compounds, and co-administration of TEE and fluoxetin at various doses could provide sedative effect on mice. The co-administration of 400 mg/kgBW extract and 15 mg/kgBW fluoxetin could provide the mean sleeping duration 43 minutes longer than positive control.

Keywords:  telang leaves ethanol extract, fluoxetin, sleeping duration

Full Text:



Amol, P.P. and Vijay, R.P., 2011, Clitoria ternatea Linn.: An Overview, Int. J. Pharm. Res., 3, 20-23. Link

Guillaume, J., Kaushik S., Bergot P. and Metailler R., 2001, Nutrition and Feeding of Fish and Crustaceans, Springer, Chichester UK: Praxis Publishing.

Harborne, J.B., 1987, Metode Fitokimia : Penuntun Cara Modern Menganalisis Tumbuhan, 1st Edition, Bandung: ITB.

Harborne, J.B., 1996, Metode Fitokimia : Penuntun Cara Modern Menganalisis Tumbuhan, 2nd Edition, Bandung : ITB.

Japardi, I., 2002, Gangguan Tidur. Surgery division, Faculty of Medicine Universitas Sumatera Utara: USU Digital Library, 1-11.

Kartikar, K.R. and Basu B.D, 1935, Indian Medicinal Plants. India : Lalit Mohan Basu Publications, Allahabad, 802.

Kulkarni, C., Pattanshetty, J.R. and Amruthraj G., 1988, Effect of Alcoholic Extract of Clitoria ternatea Linn. on Central Nervous System in Rodents, Indian J. Exp. Biol., 26(12), 957-960. Link

LeBlanc, M., Beaulieu-Bonneau, S., Mérette, C., Savard, J., Ivers, H. and Morin, C.M., 2007., Psychological And Health-Related Quality Of Life Factors Associated With Insomnia In A Populationbased Sample, J. Psychosom. Res., 63(2), 157–166. CrossRef

Mukherjee, P.K., Kumar, V., Kumar, N.S. and Heinrich, M., 2008, The Ayurvedic Medicine Clitoria ternatea from Traditional Use to Scientific Assessment, J. Ethnopharmacol, 120(3), 291-301. CrossRef

Mukherjee, P.K., Kumar, V., Kumar, N.S. and Heinrich, M., The Ayurvedic Medicine Clitoria Ternatea from Traditional Use To Scientific Assessment, J. Ethnopharmacol, 120(3), 291-301. CrossRef

Nakagawa, H., Sato M. and Gatlin III, D.M., 2007, Dietary Supplement for the Health and Quality of Cultured Fish, UK : Cromwell Press, Trowbridge.

National Sleep Foundation, 2010, How Much Sleep Do We Really Need? Washington, DC: National Sleep Foundation, Website,, accessed on February 22, 2011. Link

Ravishankar, K. and Parvathi, M., 2012, Study of Protective Effect of Ethanolic Root Extract of Clitoria Ternatea Against Stress Induced Amnesia, J. Pharm. Res., 5(5), 2763-2766. Link

Sanjayasari, Dyahruri. and Pililiang, W.G., 2011, Skrining Fitokimia dan Uji Toksisitas Ekstrak Daun Katuk (Saoropus androgenus L. Merr) terhadap Larva Udang Artemia Salina : Potensi Fitofarmaka pada Ikan, Berkala Pertanian Terubuk, 39(1), 91-100. Link

Sediarso and Rusdi, N.K., 2010, Pengaruh Ekstrak Akar Cabe Jawa (Piper retrovractum Vahl) terhadap Fertilitas Mencit Jantan Berdasarkan Peningkatan Jumlah Sperma, Usulan Hibah Kompetitif Penelitian Strategis Nasional. Pharmacy Department Faculty of Mathematics and Sciences, Jakarta: Universitas Muhammadiyah H Prof. DR. Hamka.

Setiawan, A., 2007, Mengenal Jenis Anti Nutrisi pada Bahan Pakan, Jakarta: Caron Poekphan.

Shende, V., Sahane, R., Lawar, M., Hamdulay, N. and Langote, H., 2012, Evaluation of Anti-Compulsive Effect of Ethanolic Extract of Clitoria ternatea in Mice, Asian J. Pharm. Clin. Res., 5(3), 120-123. Link


Copyright (c) 2017 Indonesian Journal of Cancer Chemoprevention

Indexed by:





Indonesian Society for Cancer Chemoprevention