Bone Resorption in Ameloblastoma and Its Underlying Mechanism

Jackson Jackson, Johni Halim, Rezky Anggraeni, Ferry Sandra

Abstract


Ameloblastoma, a tumor located in the jaw, grows slowly but locally invasive. Ameloblastoma expands in the jaw based on a mechanism resorbing the surrounding bone. To date, the bone resorption mechanisms of ameloblastoma are associated with the expression of receptor activator of nuclear factor (NF)-κB (RANK) ligand (RANKL), matrix metalloproteinases (MMPs), and tumor necrosis factor (TNF)-α. RANKL plays an important role in generating osteoclastogenesis. MMPs degrade the extracellular matrix. TNF-α can induce the formation of osteoclast and modulate the MMPs. In this review the bone resorption mechanism of ameloblastoma as well its signaling pathway will be disclosed.

Keywords: Ameloblastoma, RANKL, MMPs, TNF-α.


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DOI: http://dx.doi.org/10.14499/indonesianjcanchemoprev12iss1pp57-66

Copyright (c) 2021 Jackson Jackson, Johni Halim, Rezky Anggraeni, Ferry Sandra

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Indonesian Society for Cancer Chemoprevention