Revealing Chemopreventive Potential of Active Constituents from Medicinal Herbs Used in Indonesia for (Metastatic) Breast Cancer with Particular Molecular Targets
Abstract
Breast cancer remains as one of the highest causes of cancer-related deaths in the world, including Indonesia. In spite of following the standard protocol therapy, some patients in developing countries consume medicinal herbs as an alternative, complementary, as well as supportive therapies. Several herbs have been recognized to be used for this purpose. Annona muricata, Curcuma longa, Curcuma zanthorrhiza, Curcuma zedoaria, Phyllanthus urinaria, Gynura procumbens, Garcinia mangostana, Morinda citrifolia, and Nigella sativa are some of the plants used as chemopreventive agents with several formulas. Various types of extracts of Annona muricata show anticancer activities in vitro and in vivo. Curcumin, obtained from Curcuma longa and Curcuma zanthorrhiza, acts as p53 regulator and pro-oxidant in MCF-7 cells and also acts as a fatty acid synthase inhibitor in MDA-MB-231 cells. Xanthorrhizol from Curcuma zanthorrhiza has pro-apoptotic activity via modulation of Bcl-2, p53, and PARP-1 protein levels. Curcuma zedoaria contains curcumenone, curcumenol and curdion, which show pro-apoptotic activity in various cell lines and a cancer-induced mouse model. Corilagin and geraniin from Phyllanthus urinaria have different pro-apoptotic effects, in which, the corilagin-caused apoptotic effect is mediated by extrinsic and mitochondrial pathways, whereas geraniin induces apoptosis via ROS-mediated stimulation, both in MCF-7 cells. Thymoquinone from Nigella sativa has been extensively studied for its anticancer activities in recent years. Plants are cultivated, collected and mixed depending on the use as herbal medicines. Active compounds might be formulated if deemed possible. The development of more potential derivatives is also necessary to produce more optimum anti-cancer agents. In conclusion, Indonesian plants and their active constituents show potential activities to be developed as chemopreventive agents.
Keywords: Indonesian medicinal herbs, breast cancer, active constituents, molecular targets
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Abu, N., Zamberi, N.R., Yeap, S.K., Nordin, N., Mohamad, N.E., Romli, M.F., et al., 2018, Subchronic toxicity, immunoregulation and anti-breast tumor effect of Nordamnacantal, an anthraquinone extracted from the stems of Morinda citrifolia L, BMC Complement Altern Med, 18(1), 31. CrossRef
Adewole, S.O. and Ojewole, J.A.O., 2008, Protective effects of Annona Muricata linn. (Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozoticin-treated diabetic rats, Afr J Tradit Complement Altern Med, 6(1), 30-41. CrossRef
Alhazmi, M.I., Hasan, T.N., Shafi, G., Al-Ashaf, A.H., Alfawaz, M.A. and Alshatwi, A.A., 2014, Roles of p53 and Caspases in Induction of Apoptosis in MCF- 7 Breast Cancer Cells Treated with a Methanolic Extract of Nigella Sativa Seeds, Asian Pac J Cancer Prev, 115(22), 9655-9660. CrossRef
Ali, N.M., Yeap, S.K., Abu, N., Lim, K.L., Ky, H., Pauzi, A.Z.M., et al., 2017, Synthetic curcumin derivative DK1 possessed G2/M arrest and induced apoptosis through accumulation of intracellular ROS in MCF-7 breast cancer cells, Cancer Cell Int, 17, 30. CrossRef
Anggakusuma, Yanti, Lee, M. and Hwang, J.K., 2009, Estrogenic Activity of Xanthorrhizol Isolated from Curcuma xanthorrhiza ROXB, Biol Pharm Bull, 21(11), 1892-1837. CrossRef
Aziz, M.Y.A., Abu, N., Yeap, S.K., Ho, W.Y., Omar, A.R., Ismail, N.H., et al., 2016, Combinatorial Cytotoxic Effects of Damnacanthal and Doxorubicin against Human Breast Cancer MCF-7 Cells in Vitro, Molecules, 21(9), 1228. CrossRef
Aziz, M.Y.A., Omar, A.R., Subramani, T., Yeap, S.K., Ho, W.Y., Ismail, N.H., ,et al., 2014, Damnacanthal is a potent inducer of apoptosis with anticancer activity by stimulating p53 and p21 genes in MCF-7 breast cancer cells, Oncol Lett, 7(5), 1479-1484. CrossRef
Banerjee, S., Ji, C., Mayfield, J.E., Goel, A., Xiao, J., Dixon, J.E., et al., 2018, Ancient drug curcumin impedes 26S proteasome activity by direct inhibition of dual-specificity tyrosine-regulated kinase 2, Proc Natl Acad Sci U S A, 115(32), 8155-8160. CrossRef
Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R.L., Torre, L.A. and Jemal, A., 2018, Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries, CA Cancer J Clin, 68(6), 394-424. CrossRef
Calaf, G.M., Ponce-Cusi, R. and Carrión, F., 2018, Curcumin and paclitaxel induce cell death in breast cancer cell lines, Oncol Rep, 40(4), 2381-2388. CrossRef
Castaño, P.R., Parween, S. and Pandey, A.V., 2019, Bioactivity of Curcumin on the Cytochrome P450 Enzymes of the Steroidogenic Pathway, Int J Mol Sci, 20(18), 4606. CrossRef
Cheah, Y.H., Azimahtol, H.L.P. and Abdullah, N.R., 2006, Xanthorrhizol Exhibits Antiproliferative Activity on MCF-7 Breast Cancer Cells via Apoptosis Induction, Anticancer Res., 26(6B), 4527-4534.
Cheah, Y.H., Nordin, F.J., Sarip, R., Tee, T.T., Azimahtol, H.L.P., Sirat, H.M., et al., 2009, Combined xanthorrhizol-curcumin exhibits synergistic growth inhibitory activity via apoptosis induction in human breast cancer cells MDA-MB-231, Cancer Cell Int., 9, 1. CrossRef
Cheah, Y.H., Nordin, F.J., Tee, T.T., Azimahtol, H.L.P., Abdullah, N.R. and Ismail, Z., 2008, Antiproliferative Property and Apoptotic Effect of Xanthorrhizol on MDA-MB-231 Breast Cancer Cells, Anticancer Res., 28(6A), 3677-3689.
Cheang, M.C.U., Martin, M., Nielsen, T.O., Prat, A., Voduc, D., Rodriguez-Lescure, A., et al., 2015, Defining Breast Cancer Intrinsic Subtypes by Quantitative Receptor Expression, Oncologist, 20(5), 474-482. CrossRef
Chih, H.J., Lee, A.H., Colville, L., Binns, C.W. and Xu, D., 2013, A Review of Dietary Prevention of Human Papillomavirus-Related Infection of the Cervix and Cervical Intraepithelial Neoplasia, Nutr Cancer, 65(3), 317–328. CrossRef
Chiu, T.L. and Su, C.C., 2009, Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF- κBp65 expression in breast cancer MDA-MB-231 cells, Int J Mol Med, 23(4), 468-75. CrossRef
Clafshenkel, W.P., King, T.L., Kotlarczyk, M.P., Cline, J.M., Foster, W.G., Davis, V.L., et al., 2012, Morinda citrifolia (Noni) Juice Augments Mammary Gland Differentiation and Reduces Mammary Tumor Growth in Mice Expressing the Unactivated c-erbB2 Transgene, Evid Based Complement Alternat Med, 2012, 487423. CrossRef
Clement, Y.N., Mahase, V., Jagroop, A., Kissoon, K., Maharaj, A., Mathura, P., et al., 2016, Herbal remedies and functional foods used by cancer patients attending specialty oncology clinics in Trinidad, BMC Compement Altern Med, 16(1), 399. CrossRef
Coker-Gurkan, A., Bulut, D., Genc, R., Arisan, E.D., Yerlikaya, P.O. and Palawan-Unsal, N., 2019, Curcumin prevented human autocrine growth hormone (GH) signaling mediated NF-κB activation and miR-183-96-182 cluster stimulated epithelial mesenchymal transition in T47D breast cancer cells, Mol Biol Rep, 46(1), 355-369.
Coleman, M.P., Quaresma, M., Berrino, F., Lutz, J.M., de Angelis, R., Capocaccia, R., et al., 2008, Cancer survival in five continents: a worldwide population-based study (CONCORD), Lancet Oncol, 9, 730–756. CrossRef
Daddiouaissa, D., Amid, A., Kabbashi, N.A., Fuad, F.A.A., Elnour, A.M. and Epandy, M.A.K.M.S., 2019, Antiproliferative activity of ionic liquid-graviola fruit extract against human T breast cancer (MCF-7) cell lines using flow cytometry techniques, J Ethnopharmacol, 236, 466-473. CrossRef
Dawood, H.M., Ibrahim, R.S., Shawky, E., Hammoda, H.M. and Metwally, A.M., 2018, Integrated in silico-in vitro strategy for screening of some traditional Egyptian plants for human aromatase inhibitors, J Ethnopharmacol, 224, 359-372. CrossRef
Dent, R., Hanna. W.M., Trudeau, M., Rawlinson, E., Sun, P. and Narod, S.A., 2009, Pattern of metastatic spread in triple-negative breast cancer, Breast Cancer Res Treat, 115(2), 423–428. CrossRef
Dewi, T.K., Massar, K., Ruiter, R.A. and Leonardi, T., 2019, Determinants of breast self-examination practice among women in Surabaya, Indonesia: an application of the health belief model, BMC Public Health, 19(1), 1581. CrossRef
Doi, H., Shibata, M.A., Shibata, E., Morimoto, J., Akao, Y., Iinuma, M. et al., 2009, Panaxanthone Isolated From Pericarp of Garcinia mangostana L. Suppresses Tumor Growth and Metastasis of a Mouse Model of Mammary Cancer, Anticancer Res, 29(7), 2485-2495.
Fan, H., Liang, Y., Jiang, B., Li, X., Xun, H., Sun, J. et al., 2016, Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells, Oncol Rep, 35(5), 2651-2656. CrossRef
Foster, K., Younger, N., Aiken, W., Brady-West, D. and Delgoda, R., 2017, Reliance on medicinal plant therapy among cancer patients in Jamaica, Cancer Causes Control, 28(11), 1349-1356. CrossRef
Gallardo, M., Kemmerling, U., Aguayo, F., Bleak, T.C., Muñoz, J.P. and Calaf, G.M., 2020, Curcumin rescues breast cells from epithelial-mesenchymal transition and invasion induced by anti-miR-34a, Int J Oncol, 56(2), 480-493. CrossRef
Gao, X.F., Lin, Q.L., Li, H.L., Zhang, H.Y., Su, J.Y., Wang, B., Liu, P. and Zhang, A.Q., 2014, Extracts From Curcuma zedoaria Inhibit Proliferation of Human Breast Cancer Cell MDA-MB-231 In Vitro, Evid Based Complement Alternat Med, 2014, 730678. CrossRef
George, V.C., Kumar, D.R.N., Rajkumar, V., Suresh, P.K. and Kumar, R.A., 2012, Quantitative Assessment of the Relative Antineoplastic Potential of the n-butanolic Leaf Extract of Annona Muricata Linn. in Normal and Immortalized Human Cell Lines, Asian Pac J Cancer Prev, 13(2), 699-704. CrossRef
Gooderham, N.J., Zhu, H., Lauber, S., Boyce, A. and Creton, S., 2002, Molecular and genetic toxicology of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), Mutat Res, 506-507, 91-99. CrossRef
Goreja, W.G., 2003, Black Seed: Nature’s Miracle Remedy, Amazing Herb Press.
Hamdi, O.A.A., Rahman, S.N.S.A., Awang, K., Wahab, N.A., Looi, C.Y., Thomas, N.F., et al,., 2014, Cytotoxic Constituents from the Rhizomes of Curcuma zedoaria, Scientific World Journal, 2014, 321943. CrossRef
Hansra, D.M., Silva, O., Mehta, A. and Ahn, E., 2014, Patient with Metastatic Breast Cancer Achieves Stable Disease for 5 Years on Graviola and Xeloda after Progressing on Multiple Lines of Therapy, Breast Cancer Res Treat, 3, 84-87. CrossRef
Harbeck, N., Penault-Llorca, F., Cortes, J., Gnant, M., Houssami, N., Poortmans, P., et al., 2019, Breast cancer, Nat Rev Dis Primers, 5(1), 66. CrossRef
Hew, C.S., Khoo, B.Y. and Gam, L.H., 2013, The Anti-Cancer Property of Proteins Extracted from Gynura procumbens (Lour.) Merr, PLoS One, 8(7), e68524. CrossRef
Huang, C., Wei, Y.X., Shen, M.C., Tu, Y.H., Wang, C.C., et al., 2016, Chrysin, Abundant in Morinda citrifolia Fruit Water-EtOAc Extracts, Combined with Apigenin Synergistically Induced Apoptosis and Inhibited Migration in Human Breast and Liver Cancer Cells, J Agric Food Chem, 64(21), 4235-4245. CrossRef
Huseini, H.F., Kianbakht, S., Mirshamsi, M.H. and Zarch, A.B., 2016, Effectiveness of Topical Nigella sativa Seed Oil in the Treatment of Cyclic Mastalgia: A Randomized, Triple-Blind, Active, and Placebo-Controlled Clinical Trial, Planta Med, 82(4), 285-288. CrossRef
Jain, A., Samykutty, A., Jackson, C., Browning, D., Bollag, W.B., Thangraju, M., et al., 2015, Curcumin inhibits PhIP induced cytotoxicity in breast epithelial cells through multiple molecular targets, Cancer Lett, 365(1), 122-131. CrossRef
Janakiram, N.B., Mohammed, A., Madka. V., Kumar, G. and Rao, C.V., 2016, Prevention and treatment of cancers by immune modulating nutrients, Mol Nutr Food Res, 60(6), 1275–1294. CrossRef
Jantan, I., Saputri, F.C., Qaisar, M.N. and Buang, F., 2012, Correlation between Chemical Composition of Curcuma domestica and Curcuma zanthorrhiza and Their Antioxidant Effect on Human Low-Density Lipoprotein Oxidation, Evid Based Compement Alternat Med, 2012, 438836. CrossRef
Jiang, M., Huang, O., Xie, Z., Shen, A., Liu, H., Geng, M., et al., 2013, Curcumin Induces Cell Death and Restores Tamoxifen Sensitivity in the Antiestrogen-Resistant Breast Cancer Cell Lines MCF-7/LCC2 and MCF-7/LCC9, Molecules, 18(1), 701-720. CrossRef
Jin, X. and Mu, P., 2015, Targeting Breast Cancer Metastasis, Breast Cancer (Auckl), 9(Suppl 1), 23-34. CrossRef
Kabil, N., Bayraktar, R., Kahraman, N., Mokhlis, H.A., Calin, G.A., Lopez-Berestein, G., et al., 2018, Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer, Breast Cancer Res Treat, 171(3), 593-605. CrossRef
Kaya, P., Lee, S.R., Lee, Y.H., Kwon, S.W., Yang, H., Lee, H.W., et al., 2019, Curcumae Radix Extract Decreases Mammary Tumor-Derived Lung Metastasis via Suppression of C-C Chemokine Receptor Type 7 Expression, Nutrients, 11(2), 410. CrossRef
Kazemi-Lomedasht, F., Rami, A. and Zarghami, N., 2013, Comparison of Inhibitory Effect of Curcumin Nanoparticles and Free Curcumin in Human Telomerase Reverse Transcriptase Gene Expression in Breast Cancer, Adv Pharm Bull, 3(1), 127-130. CrossRef
Kennecke, H., Yerushalmi, R., Woods, R., Cheang, M.C.U., Voduc, D., Speers, C.H., et al., 2010, Metastatic Behavior of Breast Cancer Subtypes, J Clin Oncol, 28(20), 3271–3277. CrossRef
Kenny, B.J. and McPhee, A.S., 2020, ED50. [Updated 2019 Feb 6] In: StatPearls [Internet], StatPearls Publishing.
Khokhar, A., 2013, View Point: How to Make Women Familiar with their Breasts?, Asian Pac J Cancer Prev, 14(9), 5539–5542. CrossRef
Kim, H.I., Huang, H., Cheepala, S., Huang, S. and Chung, J., 2008, Curcumin Inhibition of Integrin (α6β4)-Dependent Breast Cancer Cell Motility and Invasion, Cancer Prec Res (Phila), 1(5), 385-391. CrossRef
Kim, J.M., Noh, E.M., Kwon, K.B., Kim, J.S., You, Y.O., Hwang, J.K., et al., 2012, Curcumin suppresses the TPA-induced invasion through inhibition of PKCα-dependent MMP-expression in MCF-7 human breast cancer cells, Phytomedicine, 19(12), 1085-1092. CrossRef
Kim, J.Y., Dao, T.T.P., Song, K., Park, S.B., Jang, H., Park, M.K., et al., 2018, Annona muricata Leaf Extract Triggered Intrinsic Apoptotic Pathway to Attenuate Cancerous Features of Triple Negative Breast Cancer MDA-MB-231 Cells, Evid Based Complement Alternat Med, 2018, 7972916. CrossRef
Kritsanawong, S., Innajak, S., Imoto, M. and Watanapokasin, R., 2016, Antiproliferative and apoptosis induction of α-mangostin in T47D breast cancer cells, Int J Oncol, 48(5), 2155-2165. CrossRef
Kurose, H., Shibata, M.A., Iinuma, M. and Otsuki, Y., 2012, Alterations in Cell Cycle and Induction of Apoptotic Cell Death in Breast Cancer Cells Treated with α-Mangostin Extracted from Mangosteen Pericarp, J Biomed Biotechnol, 2012, 672428. CrossRef
Larasati, Y.A., Yoneda-Kato, N., Nakamae, I., Yokoyama, T., Meiyanto, E. and Kato, J., 2018, Curcumin targets multiple enzymes involved in the ROS metabolic pathway to suppress tumor cell growth, Sci Rep, 8(1), 2039. CrossRef
Lauber, S.N. and Gooderham, N.J., 2007, The Cooked Meat–Derived Genotoxic Carcinogen 2-Amino-3-Methylimidazo[4,5-b]Pyridine Has Potent Hormone-Like Activity: Mechanistic Support for a Role in Breast Cancer, Cancer Res, 67(19), 9597-9602. CrossRef
Lauver, D., 1987, Theoretical perspectives relevant to breast self-examination, Adv Nursing Sci, 9(4), 16–24. CrossRef
Lee, S.H., Jaganath, I.B., Atiya, N., Manikam, R. and Sekaran, S.D., 2016, Suppression of ERK1/2 and hypoxia pathways by four Phyllanthus species inhibits metastasis of human breast cancer cells, J Food Drug Anal, 24(4), 855-865. CrossRef
Lee, S.H., Jaganath, I.B., Wang, S.M. and Sekaran, S.D., 2011, Antimetastatic Effects of Phyllanthus on Human Lung (A549) and Breast (MCF-7) Cancer Cell Lines, PLoS One, 6(6), e20994.
Lestari, B., Nakamae, I., Yoneda-Kato, N., Morimoto, T., Kanaya, S., Yokoyama, Y., et al., 2019, Pentagamavunon-1 (PGV-1) inhibits ROS metabolic enzymes and suppresses tumor cell growth by inducing M phase (prometaphase) arrest and cell senescence, Sci Rep, 9(1), 14867. CrossRef
Li, J., Bian, W.H., Wan, J., Zhou, J., Lin, Y., Wang, J.R., et al., 2014, Curdione Inhibits Proliferation of MCF-7 Cells by Inducing Apoptosis, Asian Pac J Cancer Prev, 15(22), 9997-10001. CrossRef
Linjawi, S.A.A., Khalil, W.K.B., Hassanane, M.M. and Ahmed, E.S., 2015, Evaluation of the protective effect of Nigella sativa extract and its primary active component thymoquinone against DMBA-induced breast cancer in female rats, Arch Med Sci, 11(1), 220-229. CrossRef
Lobo, R., Prabhu, K.S., Shirwaikar, A. and Shirwaikar, A., 2009, Curcuma zedoaria Rosc. (white turmeric): a review of its chemical, pharmacological and ethnomedicinal properties, J Pharm Pharmacol, 61(1), 13-21. CrossRef
Marchiori, D. and Zanello, P.P., 2017, Efficacy of N-acetylcysteine, D-mannose and Morinda citrifolia to Treat Recurrent Cystitis in Breast Cancer Survivals, In Vivo, 31(5), 931-936. CrossRef
Martinez, N., Herrera, M., Frías, L., Provencio, M., Pérez-Carrión, R., Díaz, V., et al., 2018, A combination of hydroxytyrosol, omega-3 fatty acids and curcumin improves pain and inflammation among early stage breast cancer patients receiving adjuvant hormonal therapy: results of a pilot study, Clin Transl Oncol, 21(4), 489-498. CrossRef
Martino, E., Casamassima, G., Castiglione, S., Cellupica, S., Pantalone, S., Papagni, F., et al., 2018, Vinca alkaloids and analogues as anti-cancer agents: Looking back, peering ahead, Bioorg Med Chem Lett, 28(17), 2816-2826. CrossRef
McPherson, K., Steel, C.M. and Dixon, J., 2000, ABC of breast disease: Breast cancer—epidemiology, risk factors, and genetics, BMJ, 321(7261), 624–628. CrossRef
Mittal, L., Aryal, U.K., Camarillo, I.G., Raman, V. and Sundararajan, R., 2020, Effective electrochemotherapy with curcumin in MDA-MB-231-human, triple negative breast cancer cells: A global proteomics study, Bioelectrochemistry, 131, 107350. CrossRef
Moongkarndi, P., Jaisupa, N., Samer, J., Kosem, N., Konlata, J., Rodpai, E., et al., 2014, Comparison of the biological activity of two different isolates from mangosteen, J Pharm Pharmacol, 66(8), 1171-1179. CrossRef
Najmuddin, S.U.F.S., Romli, M.F., Hamid, M., Alitheen, N.B. and Rahman, N.M.A.N.A., 2016, Anti-cancer effect of Annona Muricata Linn Leaves Crude Extract (AMCE) on breast cancer cell line, BMC Complement Altern Med, 16(1), 311. CrossRef
Nauman, M.C., Tocmo, R., Vemu, B., Veenstra, J.P. and Johnson, J.J., 2020, Inhibition of CDK2/CyclinE1 by xanthones from the mangosteen (Garcinia mangostana): a structure-activity relationship study, Nat Prod Res, 21, 1-15.
Ng. C., Pathy, N.B., Taib, N.A., The, Y.C., Mun, K.S., Amiruddin, A., et al., 2011, Comparison of Breast Cancer in Indonesia and Malaysia – A Clinico-Pathological Study Between Dharmais Cancer Centre Jakarta and University Malaya Medical Center, Kuala Lumpur, Asian Pac J Cancer Prev, 12(11), 2943–2946. Link
Nugraha, A.S. and Keller, P.A., 2011, Revealing Indigenous Indonesian Traditional Medicine: Anti-infective Agents, Nat Prod Commun, 6(12), 1953–1966. CrossRef
Obolskiy, D., Pischel, I., Siriwatanametanon, N. and Heinrich, M., 2009, Garcinia mangostana L.: a phytochemical and pharmacological review, Phytoter Res, 23(8), 1047-1065. CrossRef
Oemiyati, R., Rahajeng, E. and Kristanto, A., 2011, Prevalensi Tumor dan Beberapa Faktor yang Mempengaruhinya di Indonesia, Buletin Penelitian Kesehatan, 39(4), 190–204. Link
Otsuka, C., Miura, K.F., Hatanaka, M., Wakabayashi, K. and Ishidate Jr, M., 1996, Cytogenetic effects of a food mutagen, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), and its metabolite, 2-hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine (N-OH-PhIP), on human and Chinese hamster cells in vitro, Mutat Res, 367(3), 115-121. CrossRef
Ovalle-Magellanes, B., Eugenio-Pérez, D. and Pedraza-Chaverri, J., 2017, Medicinal properties of mangosteen (Garcinia mangostana L.): a comprehensive update, Food Chem Toxicol, 109(Pt 1), 102-122. CrossRef
Palange, A.L., Mascolo, D.D., Singh, J, Franceschi, M.S.D., Carallo, C., Gnasso, A., et al., 2012, Modulating the vascular behavior of metastatic breast cancer cells by curcumin treatment, Front Oncol, 2, 161. CrossRef
Park, S.Y., Kim, Y.H., Kim, Y.H. and Lee, S.J., 2012, Aromatic-turmerone attenuates invasion and expression of MMP-9 and COX-2 through inhibition of NF-κB activation in TPA-induced breast cancer cells, J Cell Biochem, 113(12), 3653-3662. CrossRef
Periasamy, V.S., Athinarayanan, J. and Alshatwi, A.A., 2016, Anticancer activity of an ultrasonic nanoemulsion formulation of Nigella sativa L. essential oil on human breast cancer cells, Ultrason Sonochem, 31, 449-455. CrossRef
Perou, C.M., Sørlie, T., Eisen, M.B., van de Rijn, M., Rees, C.A., Pollack, C.R., et al., 2000, Molecular portraits of human breast tumours, Nature, 406(6797), 747-752. CrossRef
Piaru, S.P., Mahmud, R., Majid, A.M.S.A., Ismail, S. and Man, C.N., 2012, Chemical composition, antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia, J Sci Food Agric, 92(3), 593-597. CrossRef
Poonthananiwatkul, B., Lim, R.H.M., Howard, R.L., Pibanpaknitee, P. and Williamson, E.M., 2015, Traditional medicine use by cancer patients in Thailand, J Ethnopharmacol, 168, 100-107. CrossRef
Quispe-Soto, E.T. and Calaf, G.M., 2016, Effect of curcumin and paclitaxel on breast carcinogenesis, Int J Oncol, 49(6), 2569-2577. CrossRef
Rachmani, E.P., Suhesti, T.S. and Widiastuti, A.R., 2012, The Breast of Anticancer from Leaf Extract of Annona muricata Against Cell Line in T47D, Int J Appl Sci Technol, 2(1).
Rafati, M., Ghasemi, A., Saeedi, M., Habibi, E., Salehifar, E., Mosazadeh, M., et al., 2019, Nigella sativa L. for prevention of acute radiation dermatitis in breast cancer: A randomized, double-blind, placebo-controlled, clinical trial, Complement Ther Med, 47, 102205. CrossRef
Rajput, S., Kumar, B.N.P., Dey, K.K., Pal, I., Parekh, A. and Mandal, M., 2013, Molecular targeting of Akt by thymoquinone promotes G1 arrest through translation inhibition of cyclin D1 and induces apoptosis in breast cancer cells, Life Sci, 93(21), 783-790. CrossRef
Rohini, B., Akhter, T., Waseem, M., Khan, J., Kashif, M. and Hemelatha, S., 2019, AgNPs From Nigella sativa Control Breast Cancer: An In Vitro Study, J Environ Pathol Toxicol Oncol, 38(2), 185-194. CrossRef
Sabapati, M., Palei, N.N., Kumar, A. and Molakpogu, R.B., 2019, Solid lipid nanoparticles of Annona muricata fruit extract: formulation, optimization and in vitro cytotoxicity studies, Drug Dev Ind Pharm, 45(4), 577-586. CrossRef
Saghatelyan, T., Yananyan, A., Janoyan, N., Tadevosyan, A., Petrosyan, H., Hovhannisyan, A., et al., 2020, Efficacy and safety of curcumin in combination with paclitaxel in patients with advanced, metastatic breast cancer: A comparative, randomized, double-blind, placebo-controlled clinical trial, Phytomedicine, 70, 153218. CrossRef
Sahak, M.K.A., Kabir, N., Abbas, G., Draman, S., Hashim, N.H. and Adli, D.S.H., 2016, The Role of Nigella sativa and Its Active Constituents in Learning and Memory, Evid Based Complement Alternat Med, 2016, 6075689. CrossRef
Scolamiero, G., Pazzini, C., Bonafè, F., Guarnieri, C. and Muscari, C., 2018, Effects of α-Mangostin on Viability, Growth and Cohesion of Multicellular Spheroids Derived From Human Breast Cancer Cell Lines, Int J Med Sci, 15(1), 23-30. CrossRef
Shanmugam, M.K., Ahn, K.S., Hsu, A., Woo, C.C., Yuan, Y., Tan, K.H.B., et al., 2018, Thymoquinone Inhibits Bone Metastasis of Breast Cancer Cells Through Abrogation of the CXCR4 Signaling Axis, Front Pharmacol, 9, 1294. CrossRef
Sharma, K., Pachauri, S.D., Ahmad. H,, Arya, A., Biala, P., Agrawal, S., et al., 2016, Anticancer Effects of Extracts from the Fruit of Morinda Citrifolia (Noni) in Breast Cancer Cell Lines, Drug Res (Stuttg), 66(3), 141-147. CrossRef
Shibata, M.A., Iinuma, M., Morimoto, J., Kurose, H., Akamatsu, K., Okuno, Y., et al., 2011, α-Mangostin extracted from the pericarp of the mangosteen (Garcinia mangostana Linn) reduces tumor growth and lymph node metastasis in an immunocompetent xenograft model of metastatic mammary cancer carrying a p53 mutation, BMC Med, 9, 69. CrossRef
Shiri, S., Alizadeh, A.M., Baradaran, B., Farhanghi, B., Shanehbandi, D., Khodayari, S., et al., 2015, Dendrosomal Curcumin Suppresses Metastatic Breast Cancer in Mice by Changing M1/M2 Macrophage Balance in the Tumor Microenvironment, Asian Pac J Cancer Prev, 16(9), 3917-22. CrossRef
Steward, W.P. and Brown, K., 2013, Cancer chemoprevention: a rapidly evolving field, Br J Cancer, 109(1), 1-7. CrossRef
Suksamrarn, S., Komutiban, O., Ratananukul, P., Chimnoi, N., Lartpornmatulee, N. and Suksamrarn, A., 2006, Cytotoxic Prenylated Xanthones From the Young Fruit of Garcinia mangostana, Chem Pharm Bull (Tokyo), 54(3), 301-305. CrossRef
Sulistyoningrum, E., Rachmani, E.P.N., Baroroh, H.N. and Rujito L., 2017, Annona muricata Leaves Extract Reduce Proliferative Indexes And Improve Histological Changes In Rat’s Breast Cancer, J Appl Pharm, 7(1), 149-155. CrossRef
Sun, X.D., Liu, X.E. and Huang, D.S., 2012, Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression, Mol Med Rep, 6(6), 1267-70. CrossRef
Sutton, K.M., Greenshields, A.L. and Hoskin, D.W., 2014, Thymoquinone, A Bioactive Component of Black Caraway Seeds, Causes G1 Phase Cell Cycle Arrest and Apoptosis in Triple-Negative Breast Cancer Cells with Mutant p53, Nutr Cancer, 66(3), 408-418. CrossRef
Taokaew, S., Nunkaew, N., Siripong, P. and Phisalaphong, M., 2014, Characteristics and anticancer properties of bacterial cellulose films containing ethanolic extract of mangosteen peel, J Biomater Sci Polym Ed, 25(9), 907-22. CrossRef
Taşkin, E.I., Akgün-Dar, K., Kapucu, A., Osanç, E., Doğruman, H., Eraltan, H., et al., 2009, Apoptosis-inducing effects of Morinda citrifolia L. and doxorubicin on the Ehrlich ascites tumor in Balb-c mice, Cell Biochem Funct, 27(8), 542-546. CrossRef
Thulasiraman, P., McAndrews, D.J. and Mohiudddin, I.Q., 2014, Curcumin restores sensitivity to retinoic acid in triple negative breast cancer cells, BMC Cancer, 14, 724. CrossRef
Tong, Y., Zhang, G., Li, Y., Xu, J., Yuan, J., Zhang, B., et al., 2018, Corilagin inhibits breast cancer growth via reactive oxygen species-dependent apoptosis and autophagy, J Cell Mol Med, 22(8), 3975-3807. CrossRef
Torres, M.A.O., Magalhães, I.F.B., Mondêgo-Oliveira R, de Sá, J.C., Rocha, A.L. and Abreu-Silva, A.L., 2017, One Plant, Many Uses: A Review of the Pharmacological Applications of Morinda citrifolia, Phytoter Res, 31(7), 971-979. CrossRef
Udin Z., 2013, Cytotoxic Activity of Xanthorrhizol From Curcuma Xanthorrhiza Roxb.’s Volatile Oil Toward Ymb-l Breast Cancer Cell, Indonesia J Appl Biochem, 15, 1. CrossRef
Untch, M., Jackisch, C., Schneeweiss, A., Conrad, B., Aktas, B., Denkert, C., et al., 2016, Nab-paclitaxel versus solvent-based paclitaxel in neoadjuvant chemotherapy for early breast cancer (GeparSepto-GBG 69): a randomised, phase 3 trial, Lancet Oncol, 17(3), 345-356. CrossRef
Wang, N., Yang, B., Zhang, X., Wang, S., Zheng, Y., Li, X., et al., 2018, Network Pharmacology-Based Validation of Caveolin-1 as a Key Mediator of Ai Du Qing Inhibition of Drug Resistance in Breast Cancer, Front Pharmacol, 9, 1106. CrossRef
Wen, C., Fu, L., Huang, J., Dai, Y., Wang, B., Xu, G., et al., 2019, Curcumin reverses doxorubicin resistance via inhibition the efflux function of ABCB4 in doxorubicin-resistant breast cancer cells, Mol Med Rep, 19(6), 5162-5168. CrossRef
Woo, C.C., Hsu, A., Kumar, A.P., Sethi, G. and Tan, K.H.B., 2013, Thymoquinone Inhibits Tumor Growth and Induces Apoptosis in a Breast Cancer Xenograft Mouse Model: The Role of p38 MAPK and ROS, PLoS One, 8(10), e75356. CrossRef
Woo, C.C., Loo, S.Y., Gee, V., Yap, C.W., Sethi, G., Kumar, A.P., et al., 2011, Anticancer activity of thymoquinone in breast cancer cells: Possible involvement of PPAR- γ pathway, Biochem Pharmacol, 82(5), 464-475. CrossRef
Wu, R.W., Tucker, J.D., Sorensen, K.J., Thompson, L.H. and Felton, J.S., 1997, Differential effect of acetyltransferase expression on the genotoxicity of heterocyclic amines in CHO cells, Mutat Res, 390(1-2), 93-103. CrossRef
Yakhni, M., Briat, A., Guerrab, A.E., Furtado, L., Kwiatkowski, F., Miot-Noirault, E., Cachin, F., Penaul-Llorca, F. and Radosevic-Robin, N., 2019, Homoharringtonine, an approved anti-leukemia drug, suppresses triple negative breast cancer growth through a rapid reduction of anti-apoptotic protein abundance, Am J Cancer Res, 9(5), 1043-1060.
Yaman, E., Elfahmi, Woerdenbag, H.J. and Kayser, O., 2014, Jamu: Indonesian traditional herbal medicine towards rational phytopharmacological use, J Herb Med, 4(2), 51-73.
Yeong, K.Y., Khaw, K.Y., Takahashi, Y., Itoh, Y., Murugaiyah, V. and Suzuki, T., 2020, Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor, Bioorg Chem, 94, 103403. CrossRef
Youlden, D.R., Cramb, S.M., Yip, C.H. and Baade, P.D., 2014, Incidence and mortality of female breast cancer in the Asia- Pacific region, Cancer Biol Med, 11, 101–115. CrossRef
Zhai, J.W., Gao, C., Ma, W.D., Wang, W., Yao, L.P., Xia, X.X., Luo, M., Zu, Y.G. and Fu, Y.J., 2016, Geraniin induces apoptosis of human breast cancer cells MCF-7 via ROS-mediated stimulation of p38 MAPK, Toxicol Mech Methods, 26(5), 311-318. CrossRef
Zhou, Q.M., Sun, Y., Zhang, H., Chen, Q.L. and Su, S.B., 2017, Curcumin reduces mitomycin C resistance in breast cancer stem cells by regulating Bcl-2 family-mediated apoptosis, Cancer Cell Int, 17, 84. CrossRef
Zong, H., Wang, F., Fan, Q.X. and Wang, L.X., 2012, Curcumin inhibits metastatic progression of breast cancer cell through suppression of urokinase-type plasminogen activator by NF-kappa B signaling pathways, Mol Biol Rep, 39(4), 4803-4808. CrossRef
Zubair, H., Azin, S., Ahmad, A., Khan, M.A., Patel, G.K., Singh, S. and Singh, A.P., 2017, Cancer Chemoprevention by Phytochemicals: Nature’s Healing Touch, Molecules, 22(3). CrossRef
DOI: http://dx.doi.org/10.14499/indonesianjcanchemoprev11iss3pp168-186
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