A Review: The Emerging Nutraceutical Potential of Pumpkin Seeds
Abstract
The pumpkin belongs to the family of Cucurbitaceae, is a well-known edible plant that has been frequently used as functional food or herbal medicine. Pumpkins contain rich unsaturated fatty acids, phytoestrogens and vitamins E in their seeds that have potential pharmaceutical, nutraceutical, and cosmeceutical properties. Information regarding their nutritional components and therapeutic properties of pumpkin seeds has expanded dynamically in the recent years and this review focus on the three main components of pumpkin seeds that described before. Several types of unsaturated fatty acids are the dominant component in pumpkin seeds which can play a role in the disease prevention and promote health. Pumpkin seeds also contain the important phytoestrogen compounds, i.e., secoisolariciresinol and lariciresinol that have estrogenic-like effect such as preventing hyperlipidemia and osteoporosis for menopausal women. Phytoestrogens in pumpkin seeds also could be related to a reduced hormone-dependent tumor. Pumpkin seeds are rich in vitamin E contents as an emerging free radical scavenger, anti-aging and antioxidant such as a-tocopherol and g-tocopherol. Findings of these studies prove that patents field for the innovation product of pumpkin seeds holds promise for the future along with their immense nutraceutical properties.
Keywords : pumpkin seeds, estrogenic, anticancer, antioxidant, nutraceutical
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Abd El-Ghany, M., Dalia, A.H. and Soha, M., 2010, Biological Study on The Effect of Pumpkin Seeds and Zinc on Reproductive Potential of Male Rats. In: The 5th Arab and 2nd International Annual Scientific Conference on Recent Trends of Developing Institutional and Academic Performance in Higher Specific Education Institutions in Egypt and Arab World, Egypt: Mansoura University, pp.2384-2404, Link.
Applequist, W. L., Avula, B., Schaneberg, B. T., Wang, Y.H. and Khan, I. A., 2006, Comparative Fatty Acid Content of Seeds of Four Cucurbita Species Grown in A Common (Shared) Garden, J. Food Compost. Anal., 19, 606-611, CrossRef.
Al-Zuhair, H., Abdel-Fattah, A. A. and Abd el Latif, H. A., 1997, Efficacy of Simvastatin and Pumpkinseed Oil in The Management of Dietary-induced Hypercholesterolemia, Pharmacol. Res., 35(5), 403-408, CrossRef.
Ardabili, A.G., Farhoosh, R. and Haddad Khodaparast, M.H., 2011, Chemical Composition and Physicochemical Properties of Pumpkin Seeds (Cucurbita pepo Subsp. Pepo Var. Styriaka) Grown in Iran, J. Agr. Sci. Tech., 13, 1053-1063, Link.
Awad, A. B., von Holtz, R. L., Cone, J. P., Fink, C. S. and Chen, Y.C., 1998, b-sitosterol Inhibits The Growth of HT-29 Human Colon Cancer Cells by Activating The Sphingomyelin Cycle, Anticancer Res., 18(1A), 471-473, Link.
Bardaa, S., Ben Halima, N., Aloui, F., Mansour, R.B., Jabeur, H., Bouaziz, M., et al., 2016, Oil from Pumpkin (Cucurbita pepo L.) Seeds: Evaluation of Its Functional Properties on Wound Healing in Rats, Lipids Health Dis., 15(1), 73, CrossRef.
Caili, F., Huan, S. and Quanhong, L., 2006, A Review on Pharmacological Activities and Utilization Technologies of Pumpkin, Plant Foods Hum. Nutr., 61(2), 70-77, CrossRef.
Cerny, K., Korydylas, M., Pospisil, F., Svabensk, O. and Zajiir, B., 1971, Nutritive Value of The Winged Bean (Psophocarpus palustris Desv.), Br.J. Nutr., 26(2), 293-299, CrossRef.
Elfiky S.A., Elelaimy I.A., Hassan A.M., Ibrahim H.M. and Elsayad R.I., 2012, Protective Effect of Pumpkin Seed Oil Against Genotoxicity Induced by Azathioprine, J. Basic Appl. Zool., 65(5), 289-298, CrossRef.
Fahim, A. T., Abdel-Fattah, A. A., Agha, A. M. and Gad, M. Z., 1995, Effect of Pumpkin Seed Oil on The Level of Free Radical Scavengers Induced During Adjuvant-arthritis in Rats, Pharmacol. Res., 31(1), 73-79, CrossRef.
Friederich, C., Theurer, G. and Schiebel-Schlosser, G., 2000, Prosta Fink Forte Capsules in The Treatment of Benign Prostatic Hyperplasia. Multicentric Surveillance Study in 2245 Patients, Forsch. Komplementarmed. Klass. Naturheilkd., 7(4), 200-204, CrossRef.
Fruhwirth, G. O. and Hermetter, A., 2007, Seeds and Oil of The Styrian Oil Pumpkin: Components and Biological Activities, Eur. J. Lipid Sci.Technol., 109(11), 1128-1140, CrossRef.
Fu C.L., Shi H. and Li Q.H., 2006, A Review on Pharmacological Activities and Utilization Technologies of Pumpkin, Plant Foods Hum. Nutr., 61(2), 73-80, CrossRef.
Gemrot, F., Barouh, N., Vieu, J. P., Pioch, D. and Montet, D., 2006, Effect of Roasting on Tocopherols of Gourd Seeds (Cucurbita pepo), Gras. Aceit., 57(4), 409-414, CrossRef.
Glew, R.H., Glew, R.S., Chuang, L.T., Huang, Y.S., Millson, M., Constans, D., et al., 2006, Amino Acid, Mineral and Fatty Acid Content of Pumpkin Seeds (Cucurbita sp) and Cyperus Esculentus Nuts in the Republic of Niger, Plant Foods Hum. Nutr., 61(2), 49-54, CrossRef.
Gossell-Williams, M., Davis, A. and O’Connor, N., 2006, Inhibition of Testosterone-induced Hyperplasia of The Prostate of Sprague-dawley Rats by Pumpkin Seed Oil, J. Med. Food, 9(2), 284-286, CrossRef.
Gossell-Williams, M., Lyttle, K., Clarke, T., Gardner, M. and Simon, O., 2008, Supplementation with Pumpkin Seed Oil Improves Plasma Lipid Profile and Cardiovascular Outcomes of Female Nonovariectomized and Ovariectomized Sprague-Dawley Rats, Phytother. Res., 22(7), 873-877, CrossRef.
Guo, J.M., Xiao, B.X., Liu, D.H., Grant, M., Zhang, S., Lai, Y.F., et al., 2004, Biphasic Effect of Daidzein on Cell Growth of Human Colon Cancer Cells, Food Chem. Toxicol., 42(10), 1641-1646, CrossRef.
Hernández-Santos B., Rodríguez-Miranda J., Herman-Lara E., Torruco-Uco J.G., Carmona-García R., Juárez-Barrientos J.M., et al., 2016, Effect of Oil Extraction Assisted by Ultrasound on The Physicochemical Properties and Fatty Acid Profile of Pumpkin Seed Oil (Cucurbita pepo), Ultrason. Sonochem., 31, 429-436, CrossRef.
Hong, C.S. Kim, S. Maeng, 2009, Effects of Pumpkin Seed Oil and Saw Palmetto Oil in Korean Men with Symptomatic Benign Prostatic Hyperplasia, Nutr. Res. Pract., 3(4), 323-327, CrossRef.
Jones, P.J.H., Raeini-Sarjaz, M., Ntanios, F.Y., Vanstone, C.A., Feng, J.Y. and Parsons W.E., 2000, Modulation of Plasma Lipid Levels and Cholesterol Kinetics by Phytosterol versus Phytostanol Esters, J. Lipid Res., 41, 697-705, Link.
Kühn, H., Chaitidis, P., Roffeis, J. and Walther, M., 2007, Arachidonic Acid Metabolites in The Cardiovascular System: The Role of Lipoxygenase Isoforms in Atherogenesis with Particular Emphasis on Vascular Remodeling, J. Cardiovasc. Pharmacol., 50(9), 609-620, CrossRef.
Leung and Foster, 1996, Encyclopedia of Common Natural Ingreadients Used in Food, Drugs and Cosmetics, 2nd edition, New York: John Wiley & Sons, Inc, Link.
Mahmoud, L.H., Basiouny, S.O. and Dawoud, H.A., 2002, Treatment of Experimental Heterophyiasis with Two Plant Extracts, Areca Nut and Pumpkin Seed, J. Egypt. Soc. Parasitol., 32(2), 501-506, Link.
Makni M., Fetoui H., Gargouri N. K., Garoui E. M. and Zeghal N., 2011, Antidiabetic Effect of Flax and Pumpkin Seed Mixture Powder: Effect on Hyperlipidemia and Antioxidant Status in Alloxan Diabetic Rats, J. Diabetes Complicat., 25(5), 339-345, CrossRef.
Makni, M., Fetoui, H., Gargouri, N.K., Garoui, E.L.M., Jaber, H., Makni, J., et al., 2010, Hypolipidemic and Hepatoprotective Seeds Mixture Diet Rich in w-3 and w-6 Fatty Acids, Food Chem. Toxicol., 48(8-9), 2239-2246, CrossRef.
Mazur, W. and Adlercreutz, H., 1998, Naturally Occurring Oestrogens in Food, Pure Appl. Chem., 70(9), 1759-1776, CrossRef.
Messina, M.J. and Loprinzi, C.L., 2001, Soy for Breast Cancer Survivors: A Critical Review of The Literature, J. Nutr., 131(11), 3095S-3108S, CrossRef.
Miura, Y., 2013, The Biological Significance of w-oxidation of Fatty Acids, Proc. Jpn. Acad. Ser. B Phys. Biol. Sci., 89(8), 370-382, CrossRef.
Montesano, D., Blasi, F., Simonetti, M. S., Santini, A. and Cossignani, L., 2018, Chemical and Nutritional Characterization of Seed Oil from Cucurbita maxima L. (var. Berrettina) Pumpkin, Foods, 7(3), 30, CrossRef.
Murkovic, M., Hillebrand, A., Winkler, J., Leitner, E., and Pfann-hauser, W., 1996, Variability of Fatty Acid Content in Pumkin Seeds (Cucurbita pepo L), Z. Lebensm. Unters. Forsch., 202(4), 275-278, CrossRef.
Murkovic, M., Piironen, V., Lampi, A., Kraushofer, T., and Gerhard, S., 2004, Changes in Chemical Composition of Pumpkin Seeds During The Roasting Process for Production of Pumpkin Seed Oil (Part 1: Non-volatile Compounds), Food Chem., 84(3), 359-365, CrossRef.
Nkosi C.Z., Opoku A.R. and Terblanche S.E., 2005, Effect of Pumpkin Seed (Cucurbita pepo) Protein Isolate on The Activity Levels of Certain Plasma Enzymes in CCl4-Induced Liver Injury in Low-Protein Fed Rats, Phytother. Res., 19(4), 341-345, CrossRef.
Patel, D., Vaghasiya, J., Pancholi, S.S. and Paul, A., 2012, Terapeutic Potential of Secoisolariciresinol Diglucoside: A Plant Lignan, Int. J. Pharm. Sci. Drug Res., 4(1) 15-18, Link.
Patel, S., 2013, Pumpkin (Cucurbita sp.) Seeds as Nutraceutic: A Review on Status Quo and Scopes, Med. J. Nutrition Metab., 6(3), 183-189, CrossRef.
Phillips, K. M., Ruggio, D. M. and Ashraf-Khorassani, M., 2005, Phytosterol Composition of Nuts and Seeds Commonly Consumed in The United States, J. Agric. Food Chem., 53(24), 9436-9445, CrossRef.
Rabrenovic B.B., Dimic E.B., Novakovic M.M., Tesevic V.V. and Basic Z.N., 2014, The Most Important Bioactive Components of Cold Pressed Oil from Different Pumpkin (Cucurbita pepo L.) seeds, Food Sci. Technol., 55, 521-7, CrossRef.
Rezig, L., Chouaibi, M., Msaada, K. and Hamdi, S., 2012, Chemical Composition and Pro le Characterization of Pumpkin (Cucurbita maxima) seed oil, Ind. Crops Prod., 37, 82-87, CrossRef.
Rosano G, Vitale C, Marazzi G, Volterrani M., 2007, Menopause and Cardiovascular Disease: The Evidence, Climacteric., 10(Suppl 1), 19-24, CrossRef.
Ryan, E., Galvin, K., O’Connor, T. P., Maguire, A.R. and O’Brien, N.M., 2007, Phytosterol, Squalene, Tocopherol Content and Fatty Acid Profile of Selected Seeds, Grains, and Legumes, Plant Foods Hum. Nutr., 62(3), 85-91, CrossRef.
Sabudak, T., 2007, Fatty Acid Composition of Seed and Leaf Oils of Pumpkin, Walnut, Almond, Maize, Sunflower and Melon, Chem. Nat. Compd., 43(4), 465–467, CrossRef.
Sanders, T.H., 1980, Effects of Variety and Maturity on Lipid Class Composition of Peanut Oil, J. Am. Oil Chem.’ Soc., 1980, 57, CrossRef.
Seif, HS., 2014, Ameliorative Effect of Pumpkin Oil (Cucurbita pepo L.) Against Alcohol-induced Hepatotoxicity and Oxidative Stress in Albino Rats, Beni-Suef Univ. J. Basic Appl. Sci., 3(3), 178-185, CrossRef.
Sicilia, T., Niemeyer, H.B., Honig, D.M. and Metzler, M., 2003, Identification and Stereochemical Characterization of Lignans in Flaxseed and Pumpkin Seeds, J. Agric. Food Chem., 51(5), 1181-1188, CrossRef.
Stevenson, D.G., Eller, F.J., Wang, L., Jane, J.L., Wang, T. and Inglett, G.E, 2007, Oil and Tocopherol Content and Composition of Pumpkin Seed Oil in 12 Cultivars, J. Agric. Food Chem., 55(10), 4005-4013, CrossRef.
Thompson, L.U., Seidl, M.M., Rickard, S.E., Orcheson, L.J. and Fong, H.H.S., 1996, Antitumorigenic Effect of a Mammalian Lignan Precursor from Flaxseed, Nutr. Cancer, 26(2), 159-165, CrossRef.
Tindall H.D., 1983, Vegetables in the Crops, London: Macmillan Press.
Winkler J., 2000, The Origin and Breeding of Hull-less Seeded Styrian Oil-pumpkin Varieties in Austria, Cucurbit Genetics Coop. Rpt., 23, 101-104, CrossRef.
Xanthopoulou, M.N., Nomikos, T., Fragopoulou, E. and Antonopoulou, S., 2009, Antioxidant and Lipoxygenase Inhibitory Activities of Pumpkin Seed Extracts, Food Res. Int., 42(5-6), 641-646, CrossRef.
Xia, H.C., Feng, L.I., Zhen, L.I. and Zhang, Z.C., 2003, Purification and Characterization of Moschatin, A Novel Type I Ribosome-inactivating Protein from The Mature Seeds of Pumpkin (Cucurbita moschata), and Preparation of Its Immunotoxin Against Human Melanoma Cells, Cell Res., 13(5), 369-374, CrossRef.
Yasir M., Sultana B., Nigam P.S. and Owusu-Apenten R., 2016, Antioxidant and Genoprotective Activity of Selected Cucurbitaceae Seed Extracts and LC–ESIMS/MS Identification of Phenolic Components, Food Chem., 199, 307-313, CrossRef.
Zeb, A. and Ahmad, S., 2017, Changes in Acylglycerols Composition, Quality Characteristics and In vivo Effects of Dietary Pumpkin Seed Oil upon Thermal Oxidation, Front. Chem., 5, 55, CrossRef.
DOI: http://dx.doi.org/10.14499/indonesianjcanchemoprev9iss2pp92-101
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