Effect of Propolis Extract to Heal The Burns in New Zealand Rabbit

Maria Hilaria, Elisma Elisma, Adrianus L. Uhe

Abstract


Propolis contains arginine (amino acids), ferulic acid (a derivative compound cinnamic which promotes the formation of collagen), flavonoids (phenolic compounds), and other compounds that can prevent the growth of bacteria, virus, and fungi. The purpose of this study was to measure the most concentration of propolis extracts that effective to heal burns of New Zealand rabbit's.  This was an experimental study with the post-test only control group design. As many as 15 male white rabbits were divided into 5 groups which treated by  propolis extract  with concentration of 50%, 75%, 100%, positive control by bioplacenton and negative control with propylene glycol. The macroscopic observation was done with detached necrosis tissue and the growth of collagen tissue as the parameter. Data were analyzed by using the one-way ANOVA and continued by the SNK test. The results of this study indicated that the propolis extracted have potency on healing burn wound with the significance of 0.00 (p≤0,05). In the concentration of 100%, extract of propolis has  potency on healing burn wound that proportionates with bioplacenton with the significance value of 1.000 (p≥0,05). It is concluded that by increasing dose, the healing time of burn wound will be shortened.

Keywords : Propolis, healing burns, rabbit


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References


Ansel, H. and Prince, S., 2004, Pharmaceutical Calculation: The Pharmacist's Handbook, In: Aisyah, C. and Elviani E., translator, 2006 Kalkulasi Farmasetik: Panduan Untuk Apoteker, Jakarta: EGC Publishers.

Darmono, S., 2011, Buku Ajar: Farmakologi Eksperimental, Jakarta: Universitas Indonesia Press.

Departemen Kesehatan RI, 1977, Materia Madika Indonesia Jilid I, Jakarta: Departemen Kesehatan RI.

Departemen Kesehatan RI, 1979, Farmakope Indonesia Edisi III, Jakarta: Departemen Kesehatan RI.

Departemen Kesehatan RI, 1986, Sediaan Galenika, Jakarta: Departemen Kesehatan RI.

Gunawan, D. and Mulyani, S., 2004, Ilmu Obat Alam (Farmakognosi) Jilid 1, Jakarta: Penebar Swadaya.

Jalali, F.S.S., Tajik, H. and Hadian, M., 2012, Efficacy of Topical Application of Alcoholic Extract of Yarrow in the Healing Process of Experimental Burn Wounds in Rabbit, Comp. Clin. Path., 21(2), 177–181. CrossRef

Moenadjat, Y., 2001, Luka Bakar, 2nd Edition, Jakarta: Universitas Indonesia Press.

Mahani, 2011, Keajaiban Propolis Trigona, Jakarta: Pustaka Bunda.

Ningsih, D. and Pamuji, G., 2009, Potensi Propolis Trgona Spp Pandeglang Sebagai pemacu Pertumbuhan Pada Sapi Peranakan Ongele, Essay, Sekolah Pascasarjana Intitut Pertanian Bogor, Bogor. Link

Ningsih, D. and Pamuji, G., 2006, Petunjuk Praktikum Farmakologi, Surakarta: Universitas Setia Budi.

Nugroho, T., 2012, Mengungkap Tentang Luka Bakar dan Artristis Reumatoid, Yogyakarta: Nuh Medika.

Priyatna, N., 2011, Beternak dan Bisnis Kelinci Pedaging, Jakarta: AgroMedia Pustaka.

Pujilestari, R., 2007, Efek Penyembuhan Luka Bakar Krim Ekstrak Etanolik Daun Nanas (Ananas Comosus Merr) Pada Kulit Punggung Kelinci Jantan Newzealand, Essay, Universitas Muhammadiyah Surakarta, Surakarta. Link

Santoso, T., 2010, Perbedaan Kecepatan Kesembuhan Luka Bakar Antara Olesan Propolis 5% dan Teh Hijau Konsentrasi 6,4gr% Pada Tikus Putih (Rattus Norvegicus), Essay, Universitas Muhammadiyah Yogyakarta, Yogyakarta.

Sihombing, 1997, Ilmu Ternak Madu, Yogyakarta: Gadjah Mada University Press.

Sudrajat and Subana, M., 2005, Dasar-Dasar Penelitian Ilmiah, Bandung: Penerbit Pustaka Setia Bandung.

Sumardjo, D., 2008, Pengantar Kimia: Buku panduan Kuliah Mahasiswa Kedokteran dan Program Strara 1 Fakultas Bioeksakta, Jakarta: EGC Publisher.

Suranto, A., 2010, Dahsyatnya Propolis Untuk Menggempur Penyakit, Jakarta: PT. Agromedia Pustaka.

Voigt, R., 1994, Buku Pelajaran Teknologi Farmasi, 5th Edition, Yogyakarta: Gadjah Mada University Press.

Weller, B., 2005, Kamus Saku Perawat, In: Harton, A., Kamus Saku Perawat, 22nd Edition, Jakarta: EGC Publishers.




DOI: http://dx.doi.org/10.14499/indonesianjcanchemoprev7iss2pp54-59

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